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Gerlach M, Riederer P, Przuntek H, Youdim MB

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Numerous important metabolic components displayed substantial changes in their mean abundance between kidneys of control and cKOt mice, including carnitine, NAD + , flavin adenine dinucleotide (FAD + ), and flavin mononucleotide (FMN) (Figure 3F)

This excess pathway activity causes oxidative stress and Na + /K + -ATPase dysfunction

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